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Renee Wegrzyn

Things Renee Says on Podcasts

Where to Find Them

Renee Wegrzyn has been a guest on Masters of Scale .

Recently: “The AI race to save American science and reshape medicine forever” on Masters of Scale (October 2026).

What They Said

“During the pandemic, supporting testing nationwide through the work we did at Ginkgo, the number of labs across the country where the operator loads the 96-well plate in a flipped direction is like double-digit percentages. The robot didn't do anything wrong. It's the human in the loop that is still part of autonomous science that we're not observing.” — Renee Wegrzyn, Masters of Scale

Wegrzyn, skeptical of fully closed-loop autonomous labs, says labs point cameras at the robots on the assumption they'll make mistakes, while ordinary human error goes uncaptured. She sees robots as partners that take over tedious steps, like testing 50 buffer concentrations.

Masters of Scale · 2026-10-13 Permalink → Listen →
Masters of Scale Around 13:40 into the episode
Speaker 4

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Bob Safian

…for the next Sputnik moment. Let's jump back in. The very idea of experimentation, it is by its definition, you know, messy because you're not really sure where you're going. And I guess sometimes you might find things that you didn't realize, and sometimes you don't really know how you got there.

Renee Wegrzyn

…concentrations, but I can outsource that to my robotic partner ARM that's here at the lab with me. That is where I see automation, at least in the near term, really empowering the scientist before we get to a world, I don't even know when it would be, where it's full closed-loop automation. I mean, you hear about these autonomous labs, but there are, I'll tell you from during my time, even during the pandemic, supporting testing nationwide through the work we did at Ginkgo, the number of labs across the country where the operator loads the 96-well plate in a flipped direction is like double-digit percentages. The robot didn't do anything wrong. It's the human in the loop that is still part of autonomous science that we're not observing. In those labs, you have many cameras pointing at the robots because we all assume the robot's going to do something silly, but it's like just regular human error is not captured.

Bob Safian

Well, I can see as you give that example why some people though are resist it because they don't want to be caught having put something in the wrong way. I mean, none of us want to be called out for having done something the wrong way.

Renee Wegrzyn

I mean, sometimes the stakes are really high, though, right? You know, some of our diagnostics customers are delivering a genetic result to a patient. And so most scientists, I think, want to do the right thing and also want to have the information that they can be coached. By understanding where…

Bob Safian

You and your co-founder, Amory, you both worked at Ginkgo Bioworks, which focuses on genetics. Like, why not work on applying AI in that area? I mean, biotech has so much runway ahead of it. There's so many different areas.

Speaker names from our own diarization · position estimated from where the line sits in the episode
“You talked about how AI is kind of transforming drug design. We think of that as top of the funnel. Now, you can test billions of designs in silico. Some subset of those you can actually test in the lab, but we haven't seen billions new clinical trials. It's because the rest of that pipeline is still bottlenecked.” — Renee Wegrzyn, Masters of Scale

Wegrzyn, former founding director of ARPA-H, on why AI drug design hasn't yet sped up cures. The physical steps, transferring assays between labs and scaling up manufacturing, are no faster than before, which is what her company is trying to fix.

Masters of Scale · 2026-10-13 Permalink → Listen →
Masters of Scale Around 09:54 into the episode
Renee Wegrzyn

…science is vast for needed to repeat things just because of just the lack of understanding of what happened. Sometimes you don't ever find out what went wrong. It's disappointing the amount of discoveries that we probably just lose to some sort of procedural variation that we haven't picked up on.

Bob Safian

So, some of this is about saving costs, and some of it is about accelerating the discovery process by pointing you in the right directions.

Renee Wegrzyn

You talked about how AI is kind of transforming drug design. We think of that as top of the funnel. Now, you can test billions of designs in silico. Some subset of those you can actually test in the lab, but we haven't seen billions new clinical trials. It's because the rest of that pipeline is still bottlenecked. We're not transferring the assays between labs faster than we were before. We're not scaling up manufacturing faster than we did before or better and with more choices than we did before. And that's really this physical AI infrastructure that we're creating is intended to just kind of break open some of those bottlenecks so that we can do one-shot tech transfer of manufacturing to scale up quickly, which is important to get cures to patients faster, candidly.

Bob Safian

Now, I could see some people looking at your data capture process as a kind of surveillance within labs. Do you get that pushback that scientists who don't want to be watched?

Renee Wegrzyn

Yes, we get that a lot. And I think it's something that my co-founder and I care really deeply about: we're doing this for the scientists. We want scientists to be top of license. If a scientist is successful, like we all win, right? Humanity wins if science is successful. And so, how can we…

Bob Safian

The bottleneck that you refer to makes me wonder, think about like science being less rigorous than maybe we've always been led to believe. I mean, I know there's been rising skepticism in certain places, including within the Trump White House, about assertions of expertise and even published…

Speaker names from our own diarization · position estimated from where the line sits in the episode

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