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MS Martin Shkreli On All-In with Chamath, Jason, Sacks & Friedberg

“I don't think there'll be a single AI-relevant drug in the next 10 years. AI does not help drug discovery. … It's pretty hard to do. And we've had computers for a long time. I built a Cray cluster to analyze drugs. Now I can use GPUs. It's great. But there isn't much AI can help us with in drug discovery.”

All-In with Chamath, Jason, Sacks & Friedberg · Money & Markets · October 2026

“I don't think there'll be a single AI-relevant drug in the next 10 years. AI does not help drug discovery. … It's pretty hard to do. And we've had computers for a long time. I built a Cray cluster to analyze drugs. Now I can use GPUs. It's great. But there isn't much AI can help us with in drug discovery.” — Martin Shkreli, All-In with Chamath, Jason, Sacks & Friedberg

Asked about effective accelerationism, Shkreli calls AI fear-mongering ridiculous and takes aim at Dario Amodei's predictions of mass unemployment and cured diseases. He then asks the audience to raise a hand if they've ever gotten a drug through FDA approval.

All-In with Chamath, Jason, Sacks & Friedberg · 2026-10-12 Listen to the episode → More from Martin Shkreli → More Money & Markets quotes →

Transcript

All-In with Chamath, Jason, Sacks & Friedberg Around 17:15 into the episode
Martin Shkreli

Effective accelerationism.

Speaker 4

Effective accelerationism. Which means. Which means? That's

Martin Shkreli

…unemployed within one to five years, about two years ago. Well, he's got three years left. He also said that we'd cure all diseases. I don't think there'll be a single AI-relevant drug in the next 10 years. AI does not help drug discovery. If you've ever built drugs, and raise your hand, if you've made a drug, gotten FDA approval for a drug. Okay, I'm pretty sure that's it. It's pretty hard. It's pretty hard to do. And we've had computers for a long time. I built a Cray cluster to analyze drugs. Now I can use GPUs. It's great. But there isn't much AI can help us with in drug discovery.

Speaker 4

What is the revenue cycle that's driving valuation? So just unpack it from a hedge funder, you're sitting there, you're like, well, you see these run rates, right? I think Jensen mentioned it yesterday. $400 billion have gone into venture that has been redirected into AI. So do you interpret that…

Martin Shkreli

I think so. That's your

Speaker 4

argument. Yeah. And I

Speaker names from our own diarization · position estimated from where the line sits in the episode

More from All-In with Chamath, Jason, Sacks & Friedberg

“At Figma, we said, hey, if you are using AI in your writing of any kind, just put at the top, written with AI. Very simple, very easy to follow. And people made jokes about it internally, but people do it. And it makes it so that we can all trust that when we see something, we know that it's been cared for enough that it's worth your time to process. And I think that we're going to see some bifurcation here around trust.” — Dylan Field, All-In with Chamath, Jason, Sacks & Friedberg “I used to believe even a few years ago, I said it at our annual user conference Config: I said the ceiling will be raised by AI. You'll be able to do greater things than before. That was wrong. The ceiling has stayed the same. AI is not raising the ceiling. Humans are raising the ceiling, though.” — Dylan Field, All-In with Chamath, Jason, Sacks & Friedberg