DW

D.A. Wallach

Things D.A. Says on Podcasts

Where to Find Them

D.A. Wallach has been a guest on The Full Ratchet (TFR): Venture Capital and Startup Investing Demystified (3 times) , This Week in Startups (2 times) , The Meb Faber Show - Better Investing (2 times) , How I Invest with David Weisburd , Odd Lots , Excess Returns , BioVenture VoiCes with Chris Garabedian , The Heart of Healthcare | A Digital Health Podcast and Invest Like the Best (Patrick O'Shaughnessy) .

Recently: “Is AI the new cigarettes? Our VC panel digs into Anthropic’s S-1 | E2356” on This Week in Startups (October 2026); “They Call It a Lottery Ticket. The Data Says Otherwise | D.A. Wallach on The Hidden Alpha of Biotech” on Excess Returns (March 2026); “Investor Stories 460: The Math Behind Venture Returns, When Sizing Matters More Than Selection, and Growth Over Discounts (Wallach, Okike, Banks)” on The Full Ratchet (TFR): Venture Capital and Startup Investing Demystified (February 2026); “Dan Rasmussen & D.A. Wallach on Biotech’s Surge, China, IPOs, US Valuations & Japan | #617” on The Meb Faber Show - Better Investing (February 2026); “Investor Stories 456: Inside Visionary Leadership: Platform Leverage, Founder Adaptability, and Market Timing (Rizik, Wang, Wallach)” on The Full Ratchet (TFR): Venture Capital and Startup Investing Demystified (January 2026); “D.A. Wallach Explains Why Biotech VC Is So Different” on Odd Lots (December 2025).

What They Said

“The thing I don't like about being anthropic right now is every person in the world has a huge financial incentive to figure out how to compete with your product cheaper. Okay. Everybody, like, it's the biggest, biggest pot of gold in human history is to figure out how to offer intelligence for free right now. So, you know, I don't like the idea of having that target on my back.” — D.A. Wallach, This Week in Startups

Wallach says betting against Anthropic's IPO in the short term would make you look like an idiot. The harder questions are about long-term defensibility, and here he names the downside of being the leader.

This Week in Startups · 2026-10-29 Permalink → Listen →
This Week in Startups Around 35:45 into the episode
Speaker 4

…think about the impact that momentum has on how well you attract people to hire. Just think about partnerships. Right now, those companies have no momentum. None. And they're just a hot. It's a tough story. They're going to be nice businesses, but they're not going to change the world anyway. Well,

Jason Calacanis

…and they put them at a different multiple on sales, different multiple on price earnings, it's just kind of like Buffett says, you know, these things are voting mechanisms and then it becomes a scale, right? Ultimately, the market. It's not a public company. So it's part of voting and not scaling.

D.A. Wallach

…with each other. It's what they've trained themselves up on over the last decade and they love it. That's a product people love. So, you know, I'm not counting anyone out yet. And I think the questions we were getting at earlier around the defensibility of Anthropic and the others, those are fascinating business questions, but they're going to play out over a longer horizon. You know, I mean, the thing I don't like about being anthropic right now is every person in the world has a huge financial incentive to figure out how to compete with your product cheaper. Okay. Everybody, like, it's the biggest, biggest pot of gold in human history is to figure out how to offer intelligence for free right now. So, you know, I don't like the idea of having that target on my back. Now, would I trade places? Sure, because they're on top of the world right now, but it's not going to be easy. And I think for those guys, one of the other interesting challenges is, and this is a credit to them, they're not commercial. You know, like Dario and the Anthropic co-founders in particular. They're not commercial. They're not in this for the money. Like, I really believe that. They…

Lon Harris

This is good.

Jason Calacanis

A DA finish. Hold on. DA finished. And then Dave. So finish your thought of why they're not commercial. And then Dave, you get to counter. Go

D.A. Wallach

for all of us craven capitalists. It is a reflection of our psychology that we cannot imagine that Dario is being genuine. Okay. It's impossible for Chamoth to listen to Dario and not see regulatory capture, venality, scam artistry. Okay, but

Speaker names come from our own diarization. The position is estimated from where the line sits in the episode.
“The actual greatest business in the history of the stock market over the past hundred years… was Altria, Philip Morris. And you go, well, why was that such a great business? Well, enormous gross margins and an incredibly addictive product with virtually unlimited demand… So I think the fundamental question for Anthropic and all the players in this market is basically, is intelligence the new cigarettes, right?” — D.A. Wallach, This Week in Startups

Jason Calacanis had just called Anthropic the greatest business in the history of capitalism, after its S-1 filing. Wallach answers with the tobacco comparison, then points to the S-1's figure that customers spend only about a tenth of a percent of operating costs on AI.

This Week in Startups · 2026-10-29 Permalink → Listen →
This Week in Startups Around 10:23 into the episode
D.A. Wallach

…so as a way of signaling how confident they are that AI is going to cure cancer. So I would view this as a very toppy signal. You know, when people are willing to literally commit suicide because they believe so much in their religion, it's interesting. I'm not sure we've ever seen it. It's like,

Jason Calacanis

no, no, I think this is the buy sign. It's the ultimate buy sign. They're literally willing to ski without a helmet. They're like, this is fine.

D.A. Wallach

It's all on the line. Now, Jason, and it didn't occur to me until you said this is the greatest business in the history of capitalism. The actual greatest business in the history of the stock market over the past hundred years, as you guys may know, was Altria, Philip Morris. And you go, well, why was that such a great business? Well, enormous gross margins and an incredibly addictive product with virtually unlimited demand. So no check. At least 10 years ago, the number I heard was still today a billion cigarette six sold every day around the world. 1 billion. So I think the fundamental question for Anthropic and all the players in this market is basically, is intelligence the new cigarettes, right? So far, a little free sample. The drug dealer's given a free sample to every company in the world, and everyone's…

Jason Calacanis

spending 2% on

Lon Harris

Claude,

D.A. Wallach

on intelligence broadly? I mean, if they're spending a tenth of a percent on Claude,

Speaker names come from our own diarization. The position is estimated from where the line sits in the episode.

Collections They Appear In